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KMID : 0360419750110020055
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Korean Journal of Pharmacology
1975 Volume.11 No. 2 p.55 ~ p.59
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Studies on the potential hazard of dichlorvos-resin vaporizing insecticide in human and domestic fowl
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吳鎭燮/Oh, J.S.
洪思岳/林定圭/金明石/申相久/尹孝仁/Hong, S.A./Lim, M.D./Kim, M.S./Shin, S.G./Yoon, H.I.
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Abstract
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Safety study of the continuous releasing dichlorvos-resin insecticide (Mopari??) was conducted in human volunteers and domestic fowls.
For the purpose, the potential hazards in using the insecticide were observed in terms of the inhibition of plasma cholinesterase activity and the changes in the liver function (GOT, GPT, Alkaline phosphatase, Bilirubin, Thymol turbidity), the blood picture (RBC, WBC with differential count, Hemoglobin, Hematocrit and ESR) and the urine picture (sugar, albumin, pH and microscopic findings) in 40 healthy adult volunteers and 60 leghorn domestic fowls. In case of the human study the observation was continued for 2 months during the application of the insectiside (1~3 solid formulations/30㎥) in the living rooms of ordinary Korean dwelling houses or in the office. In the animal test, however, 1 to 5 solid formulations of the insecticide were applied in the fowl cage of 9.2㎥ for 5 weeks.
Any significant inhibition of the plasma cholinesterase activity was not observed in both the human volunteer and the fowl throughout the experimental period. And the liver function as well as the blood and urine pictures were also not changed after exposure to the vaporizing insecticide.
It is considered from the result that the amount of dichlorvos released into the air by the continuous vaporizing dlchlorvos-resin insecticide presents no significant hazardous effect on humans or animals in the present experimental condition.
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